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Amyloid-beta clearance in Alzheimers disease


Verfasser: Masliah, Eliezer    
Verlag: Frontiers Media SA
Jahr: 2015
Umfangsangabe: 1 electronic resource (111 p.)
Grundsignatur: eBook

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Grundsignatur:
eBook
Verfasser: Verfasser: Titel:
Amyloid-beta clearance in Alzheimers disease
URL: URL: Verlag:
Frontiers Media SA
ISBN (falsch):
9782889194438
Jahr (Ansetzg):
2015
Jahr:
2015
Umfangsangabe:
1 electronic resource (111 p.)
Schrift/Sprache:
English
Schlagwort 710:
Neurosciences. Biological psychiatry. Neuropsychiatry
Schlagwort 710:
Science (General)
Abstract:
Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer's disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed
Lokal-ISN:
HL012550435